PEA‐15 (Phosphoprotein Enriched in Astrocytes 15) Is a Protective Mediator in the Vasculature and Is Regulated During Neointimal Hyperplasia

This work was supported by a grant from the Medical Research Council, UK (MR/K012789/1). Additional information can be downloaded from the publisher's websitePeer reviewedPublisher PD

Native American forum on nuclear issues presenter biography

Biograph

A versatile cis-blocking and trans-activation strategy for ribozyme characterization

Synthetic RNA control devices that use ribozymes as gene-regulatory components have been applied to controlling cellular behaviors in response to environmental signals. Quantitative measurement of the in vitro cleavage rate constants associated with ribozyme-based devices is essential for advancing the molecular design and optimization of this class of gene-regulatory devices. One of the key challenges encountered in ribozyme characterization is the efficient generation of full-length RNA from in vitro transcription reactions, where conditions generally lead to significant ribozyme cleavage. Current methods for generating full-length ribozyme-encoding RNA rely on a trans-blocking strategy, which requires a laborious gel separation and extraction step. Here, we develop a simple two-step gel-free process including cis-blocking and trans-activation steps to support scalable generation of functional full-length ribozyme-encoding RNA. We demonstrate our strategy on various types of natural ribozymes and synthetic ribozyme devices, and the cleavage rate constants obtained for the RNA generated from our strategy are comparable with those generated through traditional methods. We further develop a rapid, label-free ribozyme cleavage assay based on surface plasmon resonance, which allows continuous, real-time monitoring of ribozyme cleavage. The surface plasmon resonance-based characterization assay will complement the versatile cis-blocking and trans-activation strategy to broadly advance our ability to characterize and engineer ribozyme-based devices

Current Directions in Medical Student Well-Being

Traditionally, topics pertaining to student well-being have been conspicuously sparse throughout medical school curricula. This contradiction has been well documented in human health literature, and the academic medical community has developed strategies to respond to this need. A literature review of terms pertaining to medical student wellness was conducted to generate 34 unique articles. The articles were categorized based on three common themes: mental health, diversity, and work-life balance. In mental health, institutional changes such as professional and peer-to-peer counseling have demonstrated promising improvements. The advent of pipeline programs and student research fellowships has increased learning environment diversity. Finally, wellness programming in recreation and the arts, as well as academic shifts to pass-fail grading, have proven successful in improving work-life balance. While many of these initiatives have enriched the mental well-being of medical students, there remains a critical need to standardize these practices nationally

Planetary surface exploration: MESUR/autonomous lunar rover

Planetary surface exploration micro-rovers for collecting data about the Moon and Mars was designed by the Department of Mechanical Engineering at the University of Idaho. The goal of both projects was to design a rover concept that best satisfied the project objectives for NASA-Ames. A second goal was to facilitate student learning about the process of design. The first micro-rover is a deployment mechanism for the Mars Environmental SURvey (MESUR) Alpha Particle/Proton/X-ray instruments (APX). The system is to be launched with the sixteen MESUR landers around the turn of the century. A Tubular Deployment System and a spiked-legged walker was developed to deploy the APX from the lander to the Martian surface. While on Mars the walker is designed to take the APX to rocks to obtain elemental composition data of the surface. The second micro-rover is an autonomous, roving vehicle to transport a sensor package over the surface of the moon. The vehicle must negotiate the lunar-terrain for a minimum of one year by surviving impacts and withstanding the environmental extremes. The rover is a reliable track-driven unit that operates regardless of orientation which NASA can use for future lunar exploratory missions. A detailed description of the designs, methods, and procedures which the University of Idaho design teams followed to arrive at the final designs are included

The Saga of the Notre Dame Law School Class of 1969 “Fierce Competition, Stronger Friendships”

The Saga is a collective memorial of the Notre Dame Law School class of 1969 of their time spent at the law school. Front Matter Memorial Names Introductory Note The First of the Fighting Irish IntroductionBefore the BeginningIn the Beginning Our Class Orientation with Dean O\u27Meara First Semester Football Preliminary Matters Courses Miscellaneous Matters Social Activities Lunch with Dean O\u27Meara Food Second Semester Courses Lunch with Dean O\u27Meara Cartels and Comprehensive Exams Social Activities Summer Recess Third Semester Courses Social Activities Fourth Semester Courses Social Activities Dean Joseph O\u27Meara\u27s Retirement Robert F. Kennedy at Notre Dame MLK Candlelight Vigil The Summer of 1968 Fifth Semester Student Organizations Major Changes Courses Miscellaneous Matters Social Activities Sixth Semester Courses Shaffer as Dean Miscellaneous GraduationPost GraduationEnd PieceAppendicies A: Dean O\u27Meara\u27s letter to the Class of 1968 and 1969 B: Remembering RFK C: Robert F. Kennedy at Notre Dame, April 4, 1968, by Bob Greene D: Notre Dame Law Review E: Heir F: Principles of the Common Law G: 124th Commencement Exercises, June 1, 1969 H: 50 Year Reunion 1969–201